Earlier in the day, Liverpool travel to Southampton, with the UEFA Champions League holders facing their opening away fixture.
Manchester United are set to encounter a tough away trip on Monday against Wolverhampton Wanderers, while Chelsea host Leicester City on Sunday.
Elsewhere, Arsenal play their first home match of the season on Saturday against Burnley after the Clarets impressed during an opening 3-0 win against Southampton.
Reigning Premier League champions Manchester City began their campaign where they left off last season, with Pep Guardiola’s men slamming five past West Ham United at the London Stadium without reply.
Raheem Sterling is now a fully-fledged world-class talent, and credit must go to Guardiola for turning him into a versatile and destructive forward.
The 24-year-old’s ability to regularly find the back of the net is a trait that wasn’t present in his early career. Sterling scored a hat-trick during the opening gameweek, and if Sergio Aguero had allowed the winger to take a penalty late in the game—with Sterling keen to oblige—he could have had four.
Spurs once again failed to lift silverware under Mauricio Pochettino last term, but an appearance in the Champions League final represented progress at the club.
Thirteen Premier League defeats last season deconstructed their bid to win the title, and despite sticking close to City and Liverpool for long periods, Spurs didn’t possess the consistency needed.
Spurs’ defence was solid last season, but it’s questionable whether it boasts the pace to keep up with Sterling and City’s amazing forwards.
Pochettino’s back four was tested in the opening match against Aston Villa, and the promoted team led until a goal from Tanguy Ndombele and a brace from Harry Kane turned potential defeat into a 3-1 win.
It feels like no one can beat City on their own patch at present, and Spurs will have to produce a special performance if they want a share of the spoils.
The pressure is on United manager Ole Gunnar Solskjaer after a disastrous end to last season, when the Red Devils won just two games from their final nine to miss out on Champions League qualification when it appeared third was within touching distance.
United have reset over the summer. Harry Maguire’s arrival represented a world-record transfer fee for a defender, and the additions of Aaron Wan-Bissaka and Daniel James underlined the Red Devils’ intent to invest for the present and future.
A 4-0 victory over Chelsea in the opening weekend was just the tonic for Solskjaer, and a successful pre-season has installed vital fitness and a deeper work ethic that wasn’t present in the players last term.
Wolves were the surprise side in the top-flight last season and secured a seventh-placed finish. After winning the EFL Championship with 99 points to claim promotion in 2017-18, manager Nuno Espirito Santo guided his side to a Europa League place in 2018-19.
The Molineux club fear no team and have continued to make squad investments this summer. The permanent signing of loan star Raul Jimenez was completed last season, and the addition of Pedro Neto and Patrick Cutrone further bolsters Wolves’ attacking options.
Neto’s arrival from Lazio also strengthens Wolves’ Portuguese links, and 21-year-old Cutrone is ready to display his predatory finishing after departing AC Milan.
United will want to play on the counter-attack on the road, and Wolves’ intentions to dominate the midfield high up the pitch could leave space behind for the Red Devils to exploit.